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Tooru Shimosegawa Selected Research

Gemcitabine

12/2022[A Case of Resected Pancreatic Adenosquamous Carcinoma with Early Hepatic Metastatic Recurrence].
9/2014Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.
2/2014MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX.
5/2012Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells.
11/2011Phase I trial of neoadjuvant chemoradiation with gemcitabine and surgical resection for cholangiocarcinoma patients (NACRAC study).
12/2010Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells.
11/2005MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells.

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Tooru Shimosegawa Research Topics

Disease

64Neoplasms (Cancer)
01/2021 - 04/2002
48Pancreatic Neoplasms (Pancreatic Cancer)
12/2022 - 01/2002
43Pancreatitis
11/2022 - 01/2002
43Infections
01/2019 - 11/2003
30Fibrosis (Cirrhosis)
11/2021 - 01/2002
30Chronic Pancreatitis
06/2020 - 03/2004
23Inflammation (Inflammations)
04/2018 - 01/2002
17Hepatocellular Carcinoma (Hepatoma)
01/2018 - 10/2007
16Stomach Neoplasms (Stomach Cancer)
10/2019 - 11/2003
16Neoplasm Metastasis (Metastasis)
12/2018 - 01/2002
14Gastroesophageal Reflux (GERD)
01/2022 - 03/2004
14Crohn Disease (Crohn's Disease)
01/2019 - 10/2003
14Chronic Hepatitis C
08/2018 - 04/2002
14Pathologic Constriction (Stenosis)
03/2018 - 01/2011
13Carcinogenesis
04/2018 - 02/2007
13Autoimmune Pancreatitis
01/2017 - 05/2010
11Hemorrhage
12/2022 - 06/2006
11Non-alcoholic Fatty Liver Disease
11/2021 - 01/2008
11Ulcerative Colitis
01/2021 - 10/2003
9Carcinoma (Carcinomatosis)
01/2021 - 05/2006
9Disease Progression
11/2016 - 10/2002
9Peptic Ulcer (Peptic Ulcers)
07/2016 - 03/2004
9Atrophy
07/2015 - 11/2005
8Liver Diseases (Liver Disease)
08/2018 - 02/2006
8Hepatitis
01/2017 - 12/2002
8Abdominal Pain (Pain, Abdominal)
01/2016 - 05/2010
7Peptic Esophagitis (Reflux Esophagitis)
01/2022 - 03/2004
7Cholangitis
02/2021 - 01/2007
7Hepatitis B
01/2021 - 11/2004
7Pain (Aches)
09/2020 - 06/2006
7Ulcer
07/2016 - 01/2006
7Massive Hepatic Necrosis
01/2016 - 02/2005
7Obstructive Jaundice (Cholestatic Jaundice)
06/2014 - 01/2010
6Liver Cirrhosis (Hepatic Cirrhosis)
07/2021 - 08/2002
6Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
09/2018 - 10/2003
6Adenocarcinoma
11/2017 - 09/2006
5Adenoma (Adenomas)
01/2021 - 05/2003
5Colorectal Neoplasms (Colorectal Cancer)
01/2021 - 09/2002
5Body Weight (Weight, Body)
01/2018 - 02/2005
5Hepatitis C
01/2017 - 10/2003
5Chronic Hepatitis B
02/2015 - 11/2004
5Barrett Esophagus (Barrett's Esophagus)
05/2014 - 08/2005
4Non-Erosive Reflux Disease
01/2022 - 12/2015
4Alcoholic Fatty Liver
07/2021 - 08/2010
4Diabetes Mellitus
06/2020 - 05/2010
4Autoimmune Hepatitis
01/2020 - 06/2005

Drug/Important Bio-Agent (IBA)

21Proteins (Proteins, Gene)FDA Link
11/2022 - 02/2002
18Messenger RNA (mRNA)IBA
01/2019 - 04/2002
17SteroidsIBA
06/2018 - 01/2008
16AcidsIBA
01/2022 - 03/2004
15EnzymesIBA
01/2020 - 05/2003
14Immunoglobulin G (IgG)IBA
10/2015 - 07/2004
13Biomarkers (Surrogate Marker)IBA
11/2022 - 06/2005
13MicroRNAs (MicroRNA)IBA
01/2021 - 01/2012
10Proton Pump InhibitorsIBA
01/2021 - 01/2011
10Kazal Pancreatic Trypsin InhibitorIBA
07/2020 - 04/2004
9AntibodiesIBA
01/2019 - 07/2004
9Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2018 - 03/2004
8Antiviral Agents (Antivirals)IBA
07/2021 - 08/2006
8CytokinesIBA
11/2016 - 01/2004
8Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
07/2016 - 09/2006
7GemcitabineFDA Link
12/2022 - 11/2005
7Small Interfering RNA (siRNA)IBA
01/2018 - 12/2007
7Cadherins (E-Cadherin)IBA
01/2016 - 12/2007
6Anti-Bacterial Agents (Antibiotics)IBA
06/2020 - 06/2006
6DNA (Deoxyribonucleic Acid)IBA
09/2019 - 12/2004
6Amino AcidsFDA Link
08/2018 - 12/2009
6NucleotidesIBA
01/2017 - 04/2006
6Ribavirin (Virazole)FDA LinkGeneric
07/2016 - 05/2004
6GastrinsIBA
02/2013 - 02/2008
6InterferonsIBA
05/2010 - 04/2002
5CeruletideIBA
01/2020 - 01/2002
5Branched-Chain Amino AcidsIBA
08/2019 - 12/2009
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2019 - 09/2004
5TrypsinIBA
01/2019 - 02/2005
5RNA (Ribonucleic Acid)IBA
01/2018 - 05/2004
5Estrogens (Estrogen)FDA Link
01/2018 - 05/2003
5MucinsIBA
12/2017 - 11/2006
5Phosphotransferases (Kinase)IBA
12/2017 - 04/2002
5LigandsIBA
01/2017 - 01/2002
5Conditioned Culture MediaIBA
01/2017 - 10/2008
5Transcription Factors (Transcription Factor)IBA
01/2017 - 01/2002
5Infliximab (Remicade)FDA Link
01/2016 - 03/2010
5Immunoglobulins (Immunoglobulin)IBA
01/2015 - 04/2008
5Pepsinogen A (Pepsinogen)IBA
01/2014 - 10/2005
5NF-kappa B (NF-kB)IBA
01/2009 - 07/2002
4Protease Inhibitors (Protease Inhibitor)IBA
03/2020 - 06/2006
4Alanine Transaminase (SGPT)IBA
08/2019 - 07/2010
4Lipase (Acid Lipase)FDA Link
01/2019 - 10/2015
4Insulin (Novolin)FDA Link
01/2018 - 08/2010

Therapy/Procedure

85Therapeutics
11/2021 - 04/2002
14Drug Therapy (Chemotherapy)
11/2021 - 10/2007
10Radiotherapy
12/2022 - 05/2011
8Stents
05/2017 - 01/2002
7Pancreaticoduodenectomy
10/2020 - 04/2004
7Pancreatectomy
06/2020 - 08/2009
6Liver Transplantation
02/2021 - 02/2005
5Aftercare (After-Treatment)
01/2021 - 09/2006
5Sclerotherapy
01/2017 - 10/2004
4Conservative Treatment
02/2021 - 02/2005